Our innovation:
Innovative micelles as non-viral vectors for drug delivery (in particular for siRNA delivery) into cancer cells.
These new micelles allow the delivery of OGN in an effective and safety mode into the cells .
The micelles composition comprises biodegradable, biocompatible and low immunogenicity block copolymers and a component able to condense siRNA and improve its transfection efficiency and biological activity without toxic cell effects. This composition also allows the micelles to adopt a special self-assembly system in a non-polar solvent.
A pharmaceutical composition can be obtained in aqueous media with a therapeutically effective amount of a drug-loaded polymeric micelle together with pharmaceutically acceptable excipients and/or carriers (use as medicament).
Multifunctional delivery systems can also be developed. Those systems allow the simultaneous treatment with two or more therapeutic agents, as well as the traceability of the delivered compounds and cells when the delivered compound is a cell marker (e.g. dye).
Competitive advantages: these new nanoparticles are able to deliver into cells compounds of different nature (drug, gene, other compounds). Use for therapeutic and non-therapeutic purposes.
To be determined during further development.
Patient need addressed: cancer
Aida Castellanos Paez
