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This report is the result of a research conducted under the Minerva Market & Policy Intelligence scheme at the EU-Japan Centre for Industrial Cooperation. The objective of this report is to provide an analysis of the practices, successes and challenges of existing EU-Japan region-to-region, cluster-to-cluster and region-to-cluster cooperation, hereafter referred to as “region & cluster cooperation”. Moreover, this report will serve to give the EU-Japan Centre for Industrial Cooperation, hereafter referred to as “the Centre”, practical advice on ways to improve this type of cooperation. The scope of the research includes Japanese prefectures, EU regions, Japanese and EU regional agencies such as regional business/innovation/development agencies, Japanese and EU cluster organizations and networks, Japanese cluster promotion associations, municipalities, sector associations/consortia and R&D institutes.